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AML M4
AML M4 FAB - case report 2
Bone marrow analysis
Cytochemical staining
Immunophenotyping


Bone marrow analysis


Comment on this image collection: Bone marrow analysis performed at our institution indicated that the patient has a hypercellular marrow for his or her age. Megakaryopoiesis, is reduced, while erythropoieis and granulopoeisis are significantly reduced. The marrow contains a high-grade infiltrate of approximately 70% myeloblasts. The findings are compatible with an acute myeloid leukemia of the M4 or M5 subtype.
Bone marrow analysis performed at the outside institution showed the presence of a clearly increased blast population. These blasts are medium sized cells containing a round-oval nucleus, close chromatin, rare fine granules, and moderate cytoplasm. Granulopoiesis was less than 20% with clearly dysplastic changes. The Neutrophils are hypogranuluar to agranular with pseudopods. Erthropoiesis is increased with megaloblastoid changes, while megakaryopoiesis is increased with a sigle nucleus and hypolobulated forms. These findings are indicative of an acute monoblastic leukemia, an acute myeloid leukemia of the M5a subtype.

Differential diagnosis: Acute myeloid leukemia of the M5 subtype




Type: cytology
Source: bone marrow
Staining: panoptic stain

Low power microscopy




Type: cytology
Source: bone marrow
Staining: panoptic stain

Low power microscopy




Type: cytology
Source: bone marrow
Staining: panoptic stain




Type: cytology
Source: bone marrow
Staining: panoptic stain




Type: cytology
Source: bone marrow
Staining: panoptic stain




Type: cytology
Source: bone marrow
Staining: panoptic stain




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