Bone marrow analysis

Author(s): S. Fruehauf, A. Pitkus
Institution(s): Heidelberg University Medical Centre
Last change of this image collection: 2004/08/19

Comment on this image collection: Hypercellular bone marrow with reduced megakaryopoiesis. There is a left shift in the granulocytoid and erythroid lines. There is a myeloblast population with a monoblastoid morphology comprising 90% of the infiltration. These blasts are large with a partially rounded nucleus and partially folded oval cell nucleus. Many of the blasts also have a finely granular cytoplasm. The result is compatible with a secondary acute myeloid leukemia from a chronic myelomonocytic leukemia: AML from CMML with a classification of AML M5.

Differential diagnosis: Acute Myeloid Leukemia of the M5b subtype

Field under low power microscopy

Two blasts; the left shows a folded nucleus.

A blast with several vacuoles.

A blast with coarse granules.

Two blasts with prominent nuclei.