AML M5a FAB: Acute monocytic leukemia with predominantly monoblasts - case report 1

Author(s): S. Fruehauf, A. Pitkus
Last change: 2004/08/19

Sort of case report: In clinical view

Medical history: The patient was undergoing investigation and treatment for a respiratory infection when a complete blood count (CBC) was ordered. The patient also experienced symptoms of hot flashes and breathing difficulties.

Clinical Examination: The CBC revealed that the patient had a leukocytosis of 100 /nl. The patient was transferred to Hematology for further investigation of leukemia. A bone marrow specimen was collected and the accompanying complete blood count (CBC) results are below.

Laboratory results:

Parameter	Value	Normal value [unit]
RBC	3.3	4.3-6.1 /pl
Hemoglobin	10.7	13.-17. g/dl
Hematocrit	0.31	0.38-0.52 l/l
MCV	94	83-97 fl
Plt	39	150-440 /nl
WBC	124.70	4.0-10.0 /nl
Neutrophils		1.8-7.7 /nl
Lymphocytes		1.0-4.8 /nl
Monocytes		0.2-0.8 /nl
Eosinophils		0-0.5 /nl
Differential	not performed
Bone Marrow	Differential	Results
Blasts	97 %
Band Neutrophils	1 %
Eosinophils	1 %
Basophils	1 %

Cytogenetics: Cytogentics were ordered on a peripheral blood and a bone marrow specimen. However, there were no evaluable mitoses obtained after 24 hour and 48 hours of culture. Therefore there are no cytogenetic findings.

Diagnosis: Immunophenotyping results are suggestive of an acute myeloid leukemia with moncytic differentiation. The hematopathology indicates that this is an acute myeloid leukemia of the M5 subtype with monocytoid blasts.