Pre-T-ALL - case report 1

Author(s): S. Fruehauf, A. Pitkus, J. Dengler, S. Kraeker
Last change: 2003/04/10

Sort of case report: in clinical view

Medical history: The patient was diagnosed in our clinic.

Clinical Examination: The patient had a leucocytosis of 430/nl with 96% blasts in the peripheral blood and almost 100% blasts in the bone marrow sample. The hemoglobin was 3.9 g/dl, platelets 50 /nl, and LDH 550 U/ml.

Laboratory results:

Parameter	Value	Normal value [unit]
RBC	2.1	4.0-5.2
Hemoglobin	7.4	12.-15.
Hematocrit	0.20	0.36-0.47
MCV	97	83-97
PLT	51	150-440
WBC	430.60	4.0-10.0
Neutrophils	12.92	1.8-7.7 /nl
Monocytes		0.2-0.8 /nl
Lymphocytes	4.31	1.0-4.8 /nl
Eosinophils		0-0.5 /nl
Differential	Results
Band Neutrophils		3-10 %
Segmented Neutrophils	3	50-70 %
Lymphocytes	1	25-40 %
Atypical Lymphs
Monocytes		2-9 %
Eosinophils		2-4 %
Basophils		0-1 %
Metamyelocytes
Myelocytes
Promyelocytes
Blasts	96
Normoblasts	2	/ 100 L

Cytogenetics: No cytogenetics testing were performed on this patient.

Molecular genetics (incl. Southern blot, PCR): No Molecular Diagnostics were performed on this patient.

Diagnosis: The immunophenotyping results are consistent of a Pre T-cell acute lymphoblastic leukemia with a strong coexpression of CD13 and CD33.