Pro-T-ALL - case report 1

Author(s): S. Fruehauf, A. Pitkus
Last change: 2003/04/10

Sort of case report: in clinical view

Medical history: The patient presented to our clinic with a pancytopenia of unknown etiology and a complete blood count (CBC) was ordered with the results below. A bone marrow was ordered to further investigate the findings.

Laboratory results:

Parameter	Value	Normal value [unit]
RBC	2.5	4.0-5.2 /pl
Hemoglobin	7.0	12.-15. g/dl
Hematocrit	0.19	0.36-0.47 l/l
MCV	76	83-97 fl
Plt	104	150-440 /nl
WBC	5.09	4.0-10.0 /nl
Neutrophils	2.80	1.8-7.7 /nl
Lymphocytes	1.53	1.0-4.8 /nl
Monocytes	0.36	0.2-0.8 /nl
Eosinophils	0.10	0-0.5 /nl
Differential	Results
Band Neutrophils	2	3-10 %
Segmented Neutrophils	53	50-70 %
Lymphocytes	30	25-40 %
Atypical Lymphs	2	0 %
Monocytes	7	2-9 %
Eosinophils	2	2-4 %
Basophils	2	0-1 %
Metamyelocytes	2	0 %
Myelocytes		0 %
Promyelocytes		0 %
Blasts		0 %
Normoblasts	1	/ 100 L

Diagnosis: A population of >20% of the mononuclear cells express two early t-cell markers and lack the lineage specific myeloid markers. Therefore the diagnosis by immunophenptyping is a pro T-cell acute lymphocytic leukemia.