AML M1 FAB: Acute myeloblastic leukaemia (immature) - case report 3

Author(s): S. Fruehauf, A. Pitkus
Last change: 2004/08/19

Sort of case report: In clinical view

Medical history: The patient presented was transferred to our clinic for further diagnostic testing for an acute leukemia. The patient had a fever of one week duration.

Laboratory results:

A complete blood count (CBC) was ordered and it was found that the patient was anemic, thrombocytopenic and had a leukocytosis of 200 /nl. The peripheral blood differential showed 97% blasts. A bone marrow specimen was collected and the accompanying CBC results are below.

Parameter	Value	Normal value [unit]
RBC	3.2	4.0-5.2 /pl
Hemoglobin	8.9	12.-15. g/dl
Hematocrit	0.27	0.36-0.47 l/l
MCV	87	83-97 fl
Plt	29	150-440 /nl
WBC	198.50	4.0-10.0 /nl
Neutrophils	*	1.80-7.7 /nl
Lymphocytes	*	1.0-4.8 /nl
Monocytes	*	0.2-0.8 /nl
Eosinophils	*	0-0.5 /nl
* Differential Results	not reported due to cold agglutinin

Diagnosis: Acute myeloid leukemia of the M1 subtype

Comment on this case: The findings are consistent with an acute myeloid leukemia without HLA-DR expression, which can be associated with a translocation of genes 15 and 17. It is recommended that a correlation with cytogenetics be performed.