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The Sysmex Scientific Calendar
Sysmex Scientific Calendar 2008
Acute haemolysis
Extreme leukocytosis
Severe thrombocytopenia
Anaemia and erythrocytosis
Tumour cells
Acute leukaemia
Promyelocytic leukaemia
Reference scattergrams

The haematological emergency - Thrombocytosis - Calendar 2008 month 11

Platelet counts above 1,000,000/µL often indicate a haematological disease and (after confirmation) must be promptly reported to the treating physician. At such concentrations the incidence of thrombosis can be increased. There is also a possibility that the redundantly generated platelets are non-functional. In this case there is a danger of haemorrhage.

In extreme microcytosis of the erythocytes, for example in severe iron deficiency anaemia, the microcytes may be falsely classified as platelets when assessed by impedance counting, simulating thrombocytosis. However, in such a case fluorescent staining and counting of platelets in the optical channel will always provide a correct result. The scattergram shows a real thrombocytosis (1,023,000/µL).

In the impedance channel of a haematology analyser a falsely elevated platelet concentration of 850,000/µL was measured. This was caused by precipitated cryoglobulin in cryoglobulinaemia. The flocculated cryoglobulin is visible in the phase contrast microscope in between the erythrocyte rouleaux.

Thromobocytosis of 1,300,000/µL and platelet anisocytosis in essential thrombocythaemia (ET).

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