Arte?-Fact? - Inclusion bodies - Calendar 2007 month 5

Author(s): H. Diem (1), R. Hinzmann (2)
Institution(s): (1) Würmtal-Labor, 82131 Gauting; (2) Sysmex Europe GmbH, 22848 Norderstedt - Germany
References: The Sysmex Scientific Calendar 2007
Photos and text: Heinz Diem, MD; text: Rolf Hinzmann, MD, PhD
Last change of this image collection: 2007/01/01

During blood film inspection, and especially in the examination of erythrocytes, it is important to recognise the inclusion bodies and to distinguish between inclusions and artefacts.

An apparent Howell-Jolly body, caused by contaminated microscope oil, can be identified as an artefact by the fact that it moves independently over time (see next picture).

The artefact in the microscope oil has moved further.

Large erythrocyte with basophile stippling (between the two lymphocytes) in a case of autoimmune haemolytic anaemia (AIHA). To the right, next to the lower lymphocytes, there is a polychromatic erythrocyte.

Reticulocyte staining. Characteristic HbH cell in a case of α-thalassaemia. Today, blood films are no longer investigated for HbH cells. Instead, α-thalassaemias are diagnosed by molecular genetic tests.


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